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Brian Letzen, M.D., M.S.

Brian Letzen, M.D., M.S.
Brian Letzen, M.D., M.S.
Interventional Radiology
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Specialty Interventional Radiology
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Brian Letzen, M.D., M.S.
Brian Letzen, M.D., M.S.
Interventional Radiology

North Broward Radiologists, PA

  • Joined 2021

Specialty:

Education:

  • Yale School of Medicine, M.D., Medicine, New Haven, Connecticut, 2015
  • Johns Hopkins University, M.S., Biomedical Engineering, Baltimore, Maryland, 2010
  • University of Florida, B.S., Electrical Engineering, Gainesville, Florida, 2008

Residency and Internship Training:

  • Integrated Interventional Radiology / Diagnostic Radiology Residency: Yale-New Haven Medical Center, 2021

Fellowship Training:

  • Integrated Interventional Radiology / Diagnostic Radiology Residency: Yale-New Haven Medical Center, New Haven, Connecticut, 2021

American Board of Radiology Certification:

  • Certificate in Interventional Radiology / Diagnostic Radiology, American Board of Radiology, Board-Eligible Status, 2021

Honors / Awards:

  • RSNA Roentgen Resident/Fellow Research Award, Yale School of Medicine, New Haven, CT
  • RSNA Resident Research Grant, Yale School of Medicine, New Haven, CT
  • RSNA Travel Scholarship, Yale School of Medicine, New Haven, CT
  • WCIO Resident/Fellow In-Training Scholarship, Yale School of Medicine, New Haven, CT
  • Academic IR Symposium Travel Award, Yale School of Medicine, New Haven, CT
  • ASAIO Fellowship for Young Innovators, Yale School of Medicine, New Haven, CT
  • Global Health Travel Award (Argentina), Yale School of Medicine, New Haven, CT
  • Medical Student Research Fellowship, NIH-NCATS, Yale School of Medicine, New Haven, CT
  • Medical Student Research Fellowship, NIH-NHLBI, Yale School of Medicine, New Haven, CT
  • Medical Student Summer Research Fellowship, Yale School of Medicine, New Haven, CT
  • Four-Year Scholar, College of Engineering, University of Florida, Gainesville, FL
  • Magna Cum Laude, University of Florida, Gainesville, FL
  • Most Outstanding Senior Design Project in Electrical Engineering, University of Florida, Gainesville, FL
  • University Scholar, University of Florida, Gainesville, FL
  • General Electric Student Intern/Co-op Contribution Award, University of Florida, Gainesville, FL
  • Anderson Scholar with High Distinction, University of Florida, Gainesville, FL
  • Heta Kappa Nu Electrical Engineering Honors Society, University of Florida, Gainesville, FL Tau Beta Pi Engineering Honors Society, University of Florida, Gainesville, FL

Certification:

  • Certificate in Interventional Radiology / Diagnostic Radiology, American Board of Radiology, Board-Eligible Status, 2021

Licensure:

  • State of Florida

Hospital Affiliations:

  • Broward Health Medical Center
  • Broward Health North
  • Broward Health Coral Springs
  • Broward Health Imperial Point
  • Yale-New Haven Hospital

Associations:

  • Member, Society of Interventional Oncology
  • Member, Society of Interventional Radiology
  • Member, Radiological Society of North America
  • Editorial Board, American Society of Artificial Internal Organs

Journal

  • Vice President, Radiology Interest Group, Yale School of Medicine
  • Member, American Medical Association
  • Member, Institute of Electrical and Electronics Engineers
  • Vice President, Biomedical Engineering Society, University of Florida

Presentations / Publications:

Patents

  • US/International Patent App (PCT/US2019/045571), “Interpretable Deep Machine Learning for Clinical Radiology.” Filed: August 26, 2019, (Saul Ewing Arnstein & Lehr LLP) with Wang C, Chapiro J, Duncan J.
  • US Patent #10293090, “Percutaneous device and method for promoting movement of a bodily fluid.” Issued: May 21, 2019, (Allen & Singh) with Bonde P.
  • US Patent #7869049, “Determining biological tissue optical properties via integrating sphere spatial measurements.” Issued: Jan 11, 2011, (Scully, Scott, Murphy & Presser) with Baba JS.
  • US Patent App #12680663, “Method and apparatus for providing a wireless multiple-frequency MRI/S coil.” Filed: September 29th, 2008, (Saliwanchik, Lloyd & Saliwanchik) with Beck BL, Bashirullah R, Mareci TH.

Publications

  • Adam LC, Savic LJ, Chapiro J, Letzen B, Lin M, Georgiades C, Hong KK, Nezami N. “Response assessment methods for patients with hepatic metastasis from rare tumor primaries undergoing transarterial chemoembolization.” Clin Imaging. 2022 Sep;89:112-119. doi: 10.1016/j.clinimag.2022.06.013. Epub 2022 Jun 26. PMID: 35777239
  • Ghani MA, Fereydooni A, Chen E, Letzen B, Laage-Gaupp F, Nezami N, Deng Y, Gan G, Thakur V, Lin M, Papademetris X, Schernthaner RE, Huber S, Chapiro J, Hong K, Georgiades C. “Identifying enhancement-based staging markers on baseline MRI in patients with colorectal cancer liver metastases undergoing intra-arterial tumor therapy.” Eur Radiol. 2021 Dec;31(12):8858-8867. doi: 10.1007/s00330-021-08058-7. Epub 2021 Jun 1. PMID: 34061209
  • Letzen B, Malpani R, Miszczuk M, de Ruiter QMB, Petty CW, Rexha I, Nezami N, Laage-Gaupp F, Lin M, Schlachter TR, Chapiro. “Lipiodol as an intra-procedural imaging biomarker for liver tumor response to transarterial chemoembolization: Post-hoc analysis of a prospective clinical trial.” J. Clin Imaging. 2021 Oct;78:194-200. doi: 10.1016/j.clinimag.2021.05.007. Epub 2021 May 18. PMID: 34022765
  • “Stark S, Wang C, Savic LJ, Letzen B, Schobert I, Miszczuk M, Murali N, Oestmann P, Gebauer B, Lin M, Duncan J, Schlachter T, Chapiro J “. Automated feature quantification of Lipiodol as imaging biomarker to predict therapeutic efficacy of conventional transarterial chemoembolization of liver cancer. Sci Rep. 2020 Oct 22;10(1):18026. doi: 10.1038/s41598-020-75120-7. PMID: 33093524
  • Wang C, Hamm C, Savic L, Ferrante M, Schobert I, Schlachter T, Lin M, Weinreb J, Duncan J, Chapiro J, Letzen B. “Deep learning for liver tumor diagnosis part II: convolutional neural network interpretation using radiologic imaging features.” Eur Radiol. 2019 Jul 29 . doi: 10.1007/s00330-019-06214-8.
  • Hamm C, Wang C, Savic L, Ferrante M, Schobert I, Schlachter T, Lin M, Duncan J, Weinreb J, Chapiro J, Letzen B. “Deep learning for liver tumor diagnosis part I: development of a convolutional neural network classifier for multi-phasic MRI.” Eur Radiol. 2019 Jul 29. doi: 10.1007/s00330-019-06205-9.
  • Fereydooni A, Letzen B, Ghani M, Miszczuk M, Huber S, Chapiro J, Schlachter T, Geschwind J, Georgiades C. “Irinotecan-eluting 75-150 μm Embolics Lobar Chemoembolization in Patients with Colorectal Cancer Liver Metastases: A Prospective Single-Center Phase I Study”. Journal of Vascular and Interventional Radiology. 2018 Dec;29(12):1646-1653.e5. doi: 10.1016/j.jvir.2018.08.010.
  • Letzen B, Uppot R. “AI in IO: Big Data, Outcome Repositories, and Clinical Applications”. Endovascular Today, Vol 17. No. 10, October 2018.
  • Letzen B, Wang C, Chapiro J. “The Role of Artificial Intelligence in Interventional Oncology: A Primer”. Journal of Vascular and Interventional Radiology. 2019 Jan;30(1):38-41.e1. doi: 10.1016/j.jvir.2018.08.032.
  • Stroehl YW, Letzen BS, M van Breugel JM, Geschwind JF, Chapiro J. “Intra-arterial therapies for liver cancer: assessing tumor response.” Expert Review of Anticancer Therapy, 2016 Dec 27:1-9. doi: 10.1080/14737140.2017.1273775
  • Letzen B, Park J, Tuzun Z, Bonde P. “Design and Development of a Miniaturized Percutaneously Deployable Wireless Left Ventricular Assist Device: Early Prototypes and Feasibility Testing”. ASAIO Journal. 2018 Mar/Apr;64(2):147-153. doi: 10.1097/MAT.0000000000000669.
  • Letzen, B. “Development of a wireless percutaneous left ventricular assist device”. Medical Doctorate Thesis, Yale School of Medicine (2015).
  • Letzen BS, Matouk C, Bonde P. “Particle embolization for control of life-threatening epistaxis in a left ventricular assist device patient.” ASAIO J. 2015 Jan-Feb;61(1):102-3.
  • Chaerkady, R, Letzen, B, Renuse, S, Sahasrabuddhe, NA, Kumar, P, All, AH, Thakor, NV, Delanghe, B. Gearhart, JD, Pandey, A, Kerr, CL., “Quantitative temporal proteomic analysis of human embryonic stem cell differentiation into oligodendrocyte progenitor cells”. Proteomics, 11: 4007–4020. (2011). PMID: 21770034.
  • Letzen BS, Thakor NV, Gearhart JD, All A, Kerr C. “MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells. PLoS ONE 5(5):e10480. May 2010. PMID: 20463920
  • Kerr C, Letzen BS, Hill C, Agrawal G, Thakor NV, Sterneckert J, Gearhart JD, All A. “Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury.” Int. J. Neurosc. 120(4):305-13 (2010). PMID: 20374080
  • Letzen, B. “Optimizing ESC-derived Oligodendrocytes for Treating Demyelination & Corresponding DTI/MTI-based Monitoring Techniques”. Master of Science Thesis, Johns Hopkins University. June 2010.
  • Baba JS, Letzen BS, Ericson N, Coté GL, Xu W, Wilson MA. “Development of a multispectral tissue characterization system for optimization of an implantable perfusion status monitor for transplanted liver”. IEEE Engineering in Medicine & Biology. 6565-8. 2009. PMID: 19964906
  • Letzen BS. “Development of an implantable multiple-frequency antenna system for MRI/S of a bioartificial pancreas”. University of Florida College of Engineering. Magna cum Laude Honors Thesis. May 2008.

Presentations

  • Letzen B. Invited Oral Presentation: “Getting started with clinical machine learning research”. Society of
  • Interventional Radiology Conference, Austin, TX. March 2019.
  • Letzen B. Invited Oral Presentation: “Infrastructure for Machine Learning Research”. Spectrum: Multidisciplinary IO/IR Conference, Miami, FL. November 2018.
  • Hamm C, Wang B, Savic L, Ferrante M, Schobert I, Schlachter T, Lin M, Duncan J, Weinreb J, Chapiro J, Letzen B. Oral Presentation. “Development of a Liver Tumor Diagnosis Tool using Artificial Intelligence”. Radiological Society of North America 103rd Annual Meeting, Chicago IL. November 2018.
  • Letzen B. Invited Oral Presentation: “Machine Learning in Interventional Oncology: Infrastructure for Machine Learning Research”. World Congress on Interventional Oncology. June 2018.
  • Letzen B. Invited Panel Discussion: “Machine Learning in Interventional Oncology”. World Congress on Interventional Oncology. June 2018.
  • Letzen B. Invited Poster Presentation: “Radiologist Intuition + Computational Efficiency: The Future Synergy of Reporting and Data Systems using Artificial Intelligence / Deep Learning”. Radiological Society of North America 103rd Annual Meeting. November 2017.
  • Letzen B, Miszczuk MA, Nezami N, Laage-Gaupp F, Thakur V, Weinreb JC, Lin MD, Ruiter Q, Chapiro J, Geschwind JF. “Volumetric Quantification of Lipiodol Deposition on Cone-Beam CT: A Biomarker for Longitudinal Response after Tranarterial Chemoembolization in a Prospective Cohort”. Radiological Society of North America 103rd Annual Meeting. November 2017.
  • Letzen B. Invited Panel Discussion: “RSNA R&E Foundation Embraces Machine Learning”. Radiological Society of North America 103rd Annual Meeting. November 2017.
  • Stringam J, Letzen B, Lin M, van der Bom M, Chapiro J, Geschwind J. “Three-Dimensional Image Analysis of Hepatocellular Carcinoma on Dual-Phase Cone-Beam CT acquired immediately before Intra- Arterial Therapy: Can it be used as an early predictor of tumor response?” Society of Interventional Radiology Annual Meeting, Washington, D.D. March 2017.
  • Fereydooni A, Letzen B, Huber S, Lin M, Chapiro J, Geschwind J. “Irinotecan-eluting LC Bead-M1 (DEBIRI-M1) for Patients with Liver Metastases from Colorectal Cancer: A Phase II Single-Center Study.” Society of Interventional Radiology Annual Scientific Meeting, Washington, D.C. March 2017.
  • Ghani MA, Chapiro J, Letzen B, Thakur V, Lin M, Papademetris X, Schernthaner R, Huber S, Geschwind J. “Identifying Enhancement-based Staging Markers On Baseline MR Imaging in Patients with Colorectal Cancer Liver Metastases undergoing Loco-regional Tumor Therapy.” Society of Interventional Radiology Annual Scientific Meeting, Washington, D.C. March 2017.
  • Ali R, Letzen B, Mojibian H, Quencer K. “Pulmonary embolism after IVC filter retrieval in high risk patients: rate and potential risk factors.” Journal of Vascular and Interventional Radiology, Vol. 27, Issue 3, S14. March 2016.
  • Letzen BS, Levesque PH, Philpotts LE. Oral Presentation. “Comparison of tissue density estimation in two-dimensional synthesized mammography vs full-field digital mammography.” American Roentgen Ray Society, Toronto, Canada. 2015.
  • Letzen BS, Bouwmeester JC, Bonde P. “Design and development of a tether-free short- to intermediate- term endovascular cardiac assist device.” Oral Presentation. 22nd Annual Congress for the ISRBP, San Francisco, CA. 2014.
  • Letzen BS, Bouwmeester JC, Bonde P. “Design and development of a durable, wireless, percutaneous left ventricular assist device.” 60th Annual Conference for American Society of Artificial Internal Organs, Washington, D.C. 2014.
  • Letzen BS, Ghadyani S, Bonde P. “Varying time frame of primary graft failure after heart transplantation.” Oral Presentation. 34th Annual International Society for Heart and Lung Transplantation, San Diego, CA 2014.
  • Letzen BS, Liu F, Thakor NV, Gearhart JD, All A, Kerr C. “MicroRNA expression profiling during human embryonic stem cell differentiation into the oligodendritic lineage.” World Stem Cell Summit, Baltimore, MD 2009.
  • Kerr C, Maybhate A, Letzen BS, Agrawal G, Iyer S, Zhang J, Gearhart JD, Thakor NV, All A. “Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury.” World Stem Cell Summit, Baltimore, MD. 2009.
  • Kerr C, Hill C, Agrawal G, Letzen BS, Gearhart JD, Thakor NV, All A. “Evaluation of transplanted human embryonic stem cell-derived oligodendroglial progenitors in a rat contusion model of spinal cord injury”. Maryland Annual Stem Cell Research Symposium, Baltimore, MD (2008).
  • Beck BL, Letzen BS, Bashirullah R, Mareci TH. “Wireless control of an implantable coil system for MRI/S”. International Society for Magnetic Resonance in Medicine, Toronto, Canada. 2008.
  • Letzen BS, Beck BL, Bashirullah R, Mareci TH. “Remotely-tuned, implantable coil system for monitoring a bioartificial pancreas”. Biomedical Engineering Society Fall Meeting, Los Angeles, CA. 2007.
  • Letzen BS, Volland N, Mareci TH. “Implanted MRI coil system for in vivo imaging & spectroscopy”. University of Florida Undergraduate Research Symposium, Gainesville, FL. 2007.

Professional Societies:

  • Society of Interventional Oncology
  • Society of Interventional Radiology
  • Radiological Society of North America

Professional Experience:

  • North Broward Radiologists, P.A., Broward County, Florida
  • Resident researcher, Yale School of Medicine, New Haven, CT Interventional Oncology, Department of Radiology & Biomedical Imaging Body Imaging, Department of Radiology & Biomedical Imaging Mammography, Department of Radiology & Biomedical Imaging, 2015-2021
  • Spanish language interpreter, Yale School of Medicine, New Haven, CT HAVEN Medical Student Free Clinic, Department of Internal Medicine, 2014-2015
  • Triage assistant, Yale School of Medicine, New Haven, CT, ED Radiology, Department of Radiology & Biomedical Imaging, 2013
  • Medical student researcher, Yale School of Medicine, New Haven, CT, Mammography, Department of Radiology & Biomedical Imaging Mechanical Circulatory Support, Department of Cardiac Surgery, Nanoparticle Delivery, Department of Biomedical Engineering, 2011-2015
  • Graduate researcher, Johns Hopkins University, Baltimore, MD, Cell Engineering, Department of Biomedical Engineering, Magnetic Resonance Imaging, Department of Biomedical Engineering, 2008-2010
  • Graduate researcher, Oak Ridge National Laboratory, Oak Ridge, TN, Optical Imaging, Measurement Science & Systems Engineering Division, 2008-2009
  • Graduate teaching assistant, Johns Hopkins University, Baltimore, MD, Biomedical Modeling & Design Course, Department of Biomedical Engineering, 2008-2009
  • Undergraduate researcher, University of Florida, Gainesville, FL, Magnetic Resonance Imaging, Department of Biochemistry & Molecular Biology, 2005-2008
  • Engineering intern, General Electric, Waukesha, WI, Magnetic Resonance Imaging, GE Healthcare Division Powerplant Engineering, GE Energy Division, 2005-2006